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Registros recuperados : 19 | |
8. | | VENERONI, G. B.; MEIRELLES. S. L.; OLIVEIRA, H. N.; ALENCAR, M. M. de; GASPARIN, G.; GOUVEIA, J. J. de S.; CERVINI, M.; REGITANO, L. C. de A. Association of CSSM066 and ILSTS011 microsatellite markers and thyroglobulin gene SNP with backfat in Canchim cattle. Scientia Agricola, v. 69, n. 1, p. 1-5, feb. 2012. Biblioteca(s): Embrapa Pecuária Sudeste. |
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9. | | GOLDONI, I.; IBELLI, A. M. G.; FERNANDES, L. T.; PEIXOTO, J. de O.; HUL, L. M.; CANTAO, M. E.; GOUVEIA, J. J. de S.; LEDUR, M. C. Comprehensive analyses of bone and cartilage transcriptomes evince ion transport, inflammation and cartilage development-related genes involved in chickens femoral head separation. Animals, v. 12, n. 788, 2022. Biblioteca(s): Embrapa Suínos e Aves. |
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10. | | MELO, A. L. de; GOUVEIA, G. V.; GOUVEIA, J. J. de; MELO, N. F. de; COSTA, M. M. da; MELO, A. M. Y. de. Caracterização molecular da dinâmica de grupos bacterianos durante a transição entre área nativa e cultivada de um Argissolo da Caatinga do Sertão pernambucano. In: ENCONTRO DE GENÉTICA DO NORDESTE, 21., 2016, Recife. Anais... Ribeirão Preto: SBG; Recife: UFPE: UFRPE: UPE, 2016. p. 271. Biblioteca(s): Embrapa Semiárido. |
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11. | | SIQUEIRA, F.; TORRES JUNIOR, R. A. de A.; REGITANO, L. C. de A.; SILVA, L. O. C. da; ALENCAR, M. M. de; GOUVEIA, J. J. de; CERVINI, M. Diversidade genética de bovinos de corte por meio de marcadores microssatélites. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 46., 2009, Maringá. Anais... Maringa: SBZ:UEM, 2009. Biblioteca(s): Embrapa Pecuária Sudeste. |
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12. | | GOUVEIA, J. J. de S.; SANTIAGO, A. C.; TIZIOTO, P. C.; ESTEVES, S. N.; BARIONI JUNIOR, W.; REGITANO, L. C. de A. Estudo de associação entre microssatélites localizados no cromossomo ovino 3 e peso ao nascimento de ovinos pertencentes a três grupos genéticos. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 7., 2008, São Carlos, SP. Anais... São Carlos, SBMA, 2008. 4 p. Biblioteca(s): Embrapa Pecuária Sudeste. |
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13. | | SILVA, W. E. de L. e; GOLVEIA, G. V.; SÁ, M. da C. A. de; GOUVEIA, J. J. de; PEIXOTO, R. de M.; RIET-CORREA, F.; VESCHI, J. L. A.; COSTA, M. M. da. Bacteria isolated from abscesses of small ruminants inspected in the semiarid region of Brazil. Semina: Ciências Agrárias, Londrina, v. 37, n. 3, p. 1337-1344, maio/jun. 2016. Biblioteca(s): Embrapa Semiárido. |
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14. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; ZANELLA, R.; GOUVEIA, J. J. de S.; CANTAO, M. E.; COUTINHO, L. L.; MARCHESI, J. A. P.; DAL PIZZOL, M. S.; MARCELINO, D. E. P.; LEDUR, M. C. Downregulation of growth plate genes involved with the onset of femoral head separation in young broilers. Frontiers in Physiology, v. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134 Biblioteca(s): Embrapa Suínos e Aves. |
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15. | | CAMPOS, B. M.; CARMO, A. S. do; SILVA, T. B. R. da; VERARDO, L. L.; GOUVEIA, J. J. de S.; MALHADO, C. H. M.; SILVA, M. V. G. B.; CARNEIRO, P. L. S. Identification of artificial selection signatures in Caracu breed lines selected for milk production and meat production. Livestock Science, v. 206, p. 82-87, 2017. Biblioteca(s): Embrapa Gado de Leite. |
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16. | | SIQUEIRA, F.; TORRES JUNIOR, R. A. de A.; REGITANO, L. C. de A.; SILVA, L. O. C. da; ALENCAR, M. M. de; GOUVEIA, J. J. de S.; CERVINI, M. Diversidade genética de bovinos de corte por meio de marcadores microssatélites. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 46., 2009, Maringá. Inovação científica e tecnológica em zootecnia: anais dos resumos. Maringá: SBZ: UEM, 2009. 3 p. 1 CD-ROM. Biblioteca(s): Embrapa Gado de Corte. |
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17. | | ROSA, D. S.; OLIVEIRA, J. F. da S.; COSTA, M. M. da; MELO, A. M. Y. de; GOUVEIA, J. J. de S.; MALAGO JUNIOR, W.; REGITANO, L. C. de A.; GOUVEIA, G. V. Presence of Enterobacteriaceae and Clostridiaceae in thte soil according to the use of biofertilizers of feces from goats and sheep. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 30., 2019, Maceió. Resumos... São Paulo, SP: Sociedade Brasileira de Microbiologia -SBM, 2019. 311. Biblioteca(s): Embrapa Pecuária Sudeste. |
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18. | | MOURA, J. B.; VARGAS, A. C. de; GOUVEIA, G. V.; GOUVEIA, J. J. de S.; RAMOS-JÚNIOR, J. C.; BOTTON, S. de A.; PEREIRA, E. C.; COSTA, M. M. da. In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 4, p. 368-378, abril 2017. Título em português: Atividade antimicrobiana in vitro do extrato orgânico de Cladonia substellata Vainio e ácido úsnico frente Staphylococcus spp. obtidos de cães e gatos. Biblioteca(s): Embrapa Unidades Centrais. |
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19. | | GOUVEIA, J. J. de S.; PAIVA, S. R.; MCMANUS, C. M.; CAETANO, A. R.; KIJAS, J. W.; FACO, O.; AZEVEDO, H. C.; ARAUJO, A. M. de; SOUZA, C. J. H. de; YAMAGISHI, M. E. B.; CARNEIRO, P. L. S.; LOBO, R. N. B.; OLIVEIRA, S. M. P. de; SILVA, M. V. G. B. Genome-wide search for signatures of selection in three major Brazilian locally adapted sheep breeds. Livestock Science, n. 197, p. 36-45, 2017. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Caprinos e Ovinos; Embrapa Gado de Leite; Embrapa Meio-Norte; Embrapa Pecuária Sul; Embrapa Pesca e Aquicultura; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Tabuleiros Costeiros; Embrapa Unidades Centrais. |
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Registros recuperados : 19 | |
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Registro Completo
Biblioteca(s): |
Embrapa Suínos e Aves. |
Data corrente: |
12/08/2022 |
Data da última atualização: |
12/08/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
IBELLI, A. M. G.; PEIXOTO, J. de O.; ZANELLA, R.; GOUVEIA, J. J. de S.; CANTAO, M. E.; COUTINHO, L. L.; MARCHESI, J. A. P.; DAL PIZZOL, M. S.; MARCELINO, D. E. P.; LEDUR, M. C. |
Afiliação: |
ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; RICARDO ZANELLA, UPF; JOÃO JOSÉ DE SIMONI GOUVEIA, UNIVASF; MAURICIO EGIDIO CANTAO, CNPSA; LUIZ LEHMANN COUTINHO, Esalq; JORGE AUGUSTO PETROLI MARCHESI, USP; MARIANE SPUDEIT DAL PIZZOL, UDESC/Chapecó; DÉBORA ESTER PETRY MARCELINO, FACC; MONICA CORREA LEDUR, CNPSA. |
Título: |
Downregulation of growth plate genes involved with the onset of femoral head separation in young broilers. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Frontiers in Physiology, v. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134 |
DOI: |
https://doi.org/10.3389/fphys.2022.941134 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these findings evince that candidate genes pointed out in our study are probably related to the onset of FHS in broilers. MenosAbstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these... Mostrar Tudo |
Palavras-Chave: |
FBN2; Femoral head necrosis; FHS; Necrose da cabeça femoral; RNA-Seq. |
Thesagro: |
Frango; Galinha; Genética Animal. |
Thesaurus NAL: |
Chickens; Gene expression. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1145416/1/final9937.pdf
|
Marc: |
LEADER 02692naa a2200361 a 4500 001 2145416 005 2022-08-12 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.3389/fphys.2022.941134$2DOI 100 1 $aIBELLI, A. M. G. 245 $aDownregulation of growth plate genes involved with the onset of femoral head separation in young broilers.$h[electronic resource] 260 $c2022 520 $aAbstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these findings evince that candidate genes pointed out in our study are probably related to the onset of FHS in broilers. 650 $aChickens 650 $aGene expression 650 $aFrango 650 $aGalinha 650 $aGenética Animal 653 $aFBN2 653 $aFemoral head necrosis 653 $aFHS 653 $aNecrose da cabeça femoral 653 $aRNA-Seq 700 1 $aPEIXOTO, J. de O. 700 1 $aZANELLA, R. 700 1 $aGOUVEIA, J. J. de S. 700 1 $aCANTAO, M. E. 700 1 $aCOUTINHO, L. L. 700 1 $aMARCHESI, J. A. P. 700 1 $aDAL PIZZOL, M. S. 700 1 $aMARCELINO, D. E. P. 700 1 $aLEDUR, M. C. 773 $tFrontiers in Physiology$gv. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134
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